Lifespans of naive, memory and effector lymphocytes.

by: J Sprent

Current opinion in immunology, Vol. 5, No. 3. (June 1993), pp. 433-438.

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摘要

Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen.

@article{citeulike:2897419, abstract = {Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen.}, address = {Department of Immunology, Scripps Research Institute, La Jolla, California 92037.}, author = {Sprent, J. }, citeulike-article-id = {2897419}, issn = {0952-7915}, journal = {Current opinion in immunology}, keywords = {b\_cell, quantitative\_data, t\_cell}, month = {June}, number = {3}, pages = {433--438}, posted-at = {2008-06-16 04:05:04}, priority = {0}, title = {Lifespans of naive, memory and effector lymphocytes.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8347304}, volume = {5}, year = {1993} }

RIS record

TY - JOUR ID - citeulike:2897419 L3 - citeulike-article-id:2897419 TI - Lifespans of naive, memory and effector lymphocytes. JF - Current opinion in immunology VL - 5 IS - 3 SP - 433 EP - 438 AD - Department of Immunology, Scripps Research Institute, La Jolla, California 92037. SN - 0952-7915 N2 - Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen. KW - b_cell KW - quantitative_data KW - t_cell AU - Sprent, J PY - 1993/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/8347304 ER -

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