Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans.

by: GC Conant, A Wagner

Proceedings. Biological sciences / The Royal Society, Vol. 271, No. 1534. (7 January 2004), pp. 89-96.

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摘要

We examine robustness to mutations in the nematode worm Caenorhabditis elegans and the role of single-copy and duplicate genes in it. We do so by integrating complete genome sequence and microarray gene expression data with results from a genome-scale study using RNA interference (RNAi) to temporarily eliminate the functions of more than 16000 worm genes. We found that 89% of single-copy and 96% of duplicate genes show no detectable phenotypic effect in an RNAi knock-down experiment. We find that mutational robustness is greatest for closely related gene duplicates, large gene families and similarly expressed genes. We discuss the different causes of mutational robustness in single-copy and duplicate genes, as well as its evolutionary origin.

@article{citeulike:2899769, abstract = {We examine robustness to mutations in the nematode worm Caenorhabditis elegans and the role of single-copy and duplicate genes in it. We do so by integrating complete genome sequence and microarray gene expression data with results from a genome-scale study using RNA interference (RNAi) to temporarily eliminate the functions of more than 16000 worm genes. We found that 89\% of single-copy and 96\% of duplicate genes show no detectable phenotypic effect in an RNAi knock-down experiment. We find that mutational robustness is greatest for closely related gene duplicates, large gene families and similarly expressed genes. We discuss the different causes of mutational robustness in single-copy and duplicate genes, as well as its evolutionary origin.}, address = {Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, NM 87131, USA.}, author = {Conant, G. C. and Wagner, A. }, citeulike-article-id = {2899769}, doi = {10.1098/rspb.2003.2560}, issn = {0962-8452}, journal = {Proceedings. Biological sciences / The Royal Society}, keywords = {phenotype\_review}, month = {January}, number = {1534}, pages = {89--96}, posted-at = {2008-06-16 21:30:56}, priority = {2}, title = {Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans.}, url = {http://dx.doi.org/10.1098/rspb.2003.2560}, volume = {271}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:2899769 L3 - citeulike-article-id:2899769 TI - Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. JF - Proceedings. Biological sciences / The Royal Society VL - 271 IS - 1534 SP - 89 EP - 96 AD - Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, NM 87131, USA. SN - 0962-8452 N2 - We examine robustness to mutations in the nematode worm Caenorhabditis elegans and the role of single-copy and duplicate genes in it. We do so by integrating complete genome sequence and microarray gene expression data with results from a genome-scale study using RNA interference (RNAi) to temporarily eliminate the functions of more than 16000 worm genes. We found that 89% of single-copy and 96% of duplicate genes show no detectable phenotypic effect in an RNAi knock-down experiment. We find that mutational robustness is greatest for closely related gene duplicates, large gene families and similarly expressed genes. We discuss the different causes of mutational robustness in single-copy and duplicate genes, as well as its evolutionary origin. KW - phenotype_review AU - Conant, GC AU - Wagner, A PY - 2004/01/07/ UR - http://dx.doi.org/10.1098/rspb.2003.2560 ER -

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