RNAi as a tool to study cell biology: building the genome-phenome bridge

by: Kristin C Gunsalus, Fabio Piano

Current Opinion in Cell Biology, Vol. 17, No. 1. (February 2005), pp. 3-8.

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摘要

In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable [`]digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.

@article{citeulike:2899749, abstract = {In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable [`]digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.}, author = {Gunsalus, Kristin C. and Piano, Fabio }, citeulike-article-id = {2899749}, doi = {http://dx.doi.org/10.1016/j.ceb.2004.12.008}, journal = {Current Opinion in Cell Biology}, keywords = {phenotype\_review}, month = {February}, number = {1}, pages = {3--8}, posted-at = {2008-06-16 21:19:49}, priority = {2}, title = {RNAi as a tool to study cell biology: building the genome-phenome bridge}, url = {http://dx.doi.org/10.1016/j.ceb.2004.12.008}, volume = {17}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:2899749 L3 - citeulike-article-id:2899749 TI - RNAi as a tool to study cell biology: building the genome-phenome bridge JF - Current Opinion in Cell Biology VL - 17 IS - 1 SP - 3 EP - 8 N2 - In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable [`]digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome. KW - phenotype_review AU - Gunsalus, Kristin AU - Piano, Fabio PY - 2005/02// UR - http://dx.doi.org/10.1016/j.ceb.2004.12.008 ER -

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