Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

@article{citeulike:2799665, abstract = {In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.}, address = {Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.}, author = {Liang, W. S. and Dunckley, T. and Beach, T. G. and Grover, A. and Mastroeni, D. and Walker, D. G. and Caselli, R. J. and Kukull, W. A. and McKeel, D. and Morris, J. C. and Hulette, C. and Schmechel, D. and Alexander, G. E. and Reiman, E. M. and Rogers, J. and Stephan, D. A. }, citeulike-article-id = {2799665}, doi = {10.1152/physiolgenomics.00208.2006}, issn = {1531-2267}, journal = {Physiological genomics}, keywords = {alzheimers, lcm, microarray}, month = {February}, number = {3}, pages = {311--322}, posted-at = {2008-05-14 18:28:17}, priority = {2}, title = {Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.}, url = {http://dx.doi.org/10.1152/physiolgenomics.00208.2006}, volume = {28}, year = {2007} }

TY - JOUR ID - citeulike:2799665 L3 - citeulike-article-id:2799665 TI - Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. JF - Physiological genomics VL - 28 IS - 3 SP - 311 EP - 322 AD - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA. SN - 1531-2267 N2 - In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders. KW - alzheimers KW - lcm KW - microarray AU - Liang, WS AU - Dunckley, T AU - Beach, TG AU - Grover, A AU - Mastroeni, D AU - Walker, DG AU - Caselli, RJ AU - Kukull, WA AU - McKeel, D AU - Morris, JC AU - Hulette, C AU - Schmechel, D AU - Alexander, GE AU - Reiman, EM AU - Rogers, J AU - Stephan, DA PY - 2007/02/12/ UR - http://dx.doi.org/10.1152/physiolgenomics.00208.2006 ER -