Essentiality is an emergent property of metabolic network wiring.

by: MC Palumbo, A Colosimo, A Giuliani, L Farina

FEBS letters, Vol. 581, No. 13. (29 May 2007), pp. 2485-2489.

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摘要

The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the 'missing alternative' topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts. We demonstrate that the 'missing alternative' paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential.

@article{citeulike:2793656, abstract = {The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the 'missing alternative' topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts. We demonstrate that the 'missing alternative' paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential.}, address = {Physiology and Pharmacology Department, University of Rome Sapienza, Italy. mariaconcetta.palumbo@uniroma1.it}, author = {Palumbo, M. C. and Colosimo, A. and Giuliani, A. and Farina, L. }, citeulike-article-id = {2793656}, doi = {10.1016/j.febslet.2007.04.067}, issn = {0014-5793}, journal = {FEBS letters}, keywords = {essential, metabolic, network}, month = {May}, number = {13}, pages = {2485--2489}, posted-at = {2008-05-13 07:21:06}, priority = {2}, title = {Essentiality is an emergent property of metabolic network wiring.}, url = {http://dx.doi.org/10.1016/j.febslet.2007.04.067}, volume = {581}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2793656 L3 - citeulike-article-id:2793656 TI - Essentiality is an emergent property of metabolic network wiring. JF - FEBS letters VL - 581 IS - 13 SP - 2485 EP - 2489 AD - Physiology and Pharmacology Department, University of Rome Sapienza, Italy. mariaconcetta.palumbo@uniroma1.it SN - 0014-5793 N2 - The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the 'missing alternative' topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts. We demonstrate that the 'missing alternative' paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential. KW - essential KW - metabolic KW - network AU - Palumbo, MC AU - Colosimo, A AU - Giuliani, A AU - Farina, L PY - 2007/05/29/ UR - http://dx.doi.org/10.1016/j.febslet.2007.04.067 ER -

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