Canalization of development by microRNAs.

by: E Hornstein, N Shomron

Nat Genet, Vol. 38 Suppl 1 (June 2006)

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摘要

Animal development is an extremely robust process resulting in stereotyped outcomes. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. Recent revelations into microRNA (miRNA) function suggest that miRNAs act as key players in canalizing genetic programs. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs.

@article{citeulike:681312, abstract = {Animal development is an extremely robust process resulting in stereotyped outcomes. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. Recent revelations into microRNA (miRNA) function suggest that miRNAs act as key players in canalizing genetic programs. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs.}, address = {Eran Hornstein is in the Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. eran.hornstein@weizmann.ac.il.}, author = {Hornstein, E. and Shomron, N. }, citeulike-article-id = {681312}, doi = {10.1038/ng1803}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {microrna}, month = {June}, posted-at = {2008-06-24 10:22:35}, priority = {4}, title = {Canalization of development by microRNAs.}, url = {http://dx.doi.org/10.1038/ng1803}, volume = {38 Suppl 1}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:681312 L3 - citeulike-article-id:681312 TI - Canalization of development by microRNAs. JF - Nat Genet VL - 38 Suppl 1 AD - Eran Hornstein is in the Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. eran.hornstein@weizmann.ac.il. SN - 1061-4036 N2 - Animal development is an extremely robust process resulting in stereotyped outcomes. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. Recent revelations into microRNA (miRNA) function suggest that miRNAs act as key players in canalizing genetic programs. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs. KW - microrna AU - Hornstein, E AU - Shomron, N PY - 2006/06// UR - http://dx.doi.org/10.1038/ng1803 ER -

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