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Topology-Bayes versus Clade-Bayes in Phylogenetic Analysis

by: Ward C Wheeler, Kurt M Pickett
Mol Biol Evol (12 December 2007), msm274.


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Several features of currently used Bayesian methods in phylogenetic analysis are discussed. The distinction between Clade-Bayes and Topology-Bayes is presented and illustrated with an empirical example. Three problems with "Bayesian" phylogenetic methods|exaggerated clade support, inconsistently biased priors, and the impossibility of hypothesis testing of cladograms|are shown to be the result of using a Clade-based Bayesian approach. Topology-based Bayesian methods do not share these shortcomings. 10.1093/molbev/msm274


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