Fractional allelic imbalance could allow for the development of an equitable transplant selection policy for patients with hepatocellular carcinoma.

@article{citeulike:2951640, abstract = {Liver transplantation (LT) in the presence of hepatocellular carcinoma (HCC) remains a controversial issue because the current staging systems are not sufficiently predictive of outcomes. Paraffin blocks from 183 patients that underwent LT in the presence of HCC were collected. Molecular analysis was carried out blindly on the native liver specimens in all cases with respect to recurrence outcomes. The fractional allelic imbalance (FAI) rate index was determined in each case and was used to compare the acquired mutational load between different tumors. The FAI was determined from the microdissected tissue site displaying the greatest amount of acquired allelic loss. FAI was found to be the strongest predictor of recurrence followed by vascular invasion and then by tumor number or hepatic lobar involvement. Based on these findings, 3 prognostic models were constructed for selection of candidates for LT in patients with concomitant HCC. Molecular markers of tumor progression are the strongest predictors of HCC recurrence currently available, surpassing all components of the tumor-node-metastasis classification system for staging of malignant tumors (TNM), including vascular invasion. Incorporation of these molecular markers of tumor progression could help resolve the ongoing conundrum of organ allocation for patients with HCC.}, address = {Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-3236, USA.}, author = {Dvorchik, I. and Schwartz, M. and Fiel, M. I. and Finkelstein, S. D. and Marsh, J. W. }, citeulike-article-id = {2951640}, doi = {http://dx.doi.org/10.1002/lt.21393}, issn = {1527-6473}, journal = {Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society}, keywords = {fai\_index, hcc, hepatocellular\_carcinoma, liver\_cancer}, month = {April}, number = {4}, pages = {443--450}, posted-at = {2008-07-02 10:30:50}, priority = {2}, title = {Fractional allelic imbalance could allow for the development of an equitable transplant selection policy for patients with hepatocellular carcinoma.}, url = {http://dx.doi.org/10.1002/lt.21393}, volume = {14}, year = {2008} }

TY - JOUR ID - citeulike:2951640 L3 - citeulike-article-id:2951640 TI - Fractional allelic imbalance could allow for the development of an equitable transplant selection policy for patients with hepatocellular carcinoma. JF - Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society VL - 14 IS - 4 SP - 443 EP - 450 AD - Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-3236, USA. SN - 1527-6473 N2 - Liver transplantation (LT) in the presence of hepatocellular carcinoma (HCC) remains a controversial issue because the current staging systems are not sufficiently predictive of outcomes. Paraffin blocks from 183 patients that underwent LT in the presence of HCC were collected. Molecular analysis was carried out blindly on the native liver specimens in all cases with respect to recurrence outcomes. The fractional allelic imbalance (FAI) rate index was determined in each case and was used to compare the acquired mutational load between different tumors. The FAI was determined from the microdissected tissue site displaying the greatest amount of acquired allelic loss. FAI was found to be the strongest predictor of recurrence followed by vascular invasion and then by tumor number or hepatic lobar involvement. Based on these findings, 3 prognostic models were constructed for selection of candidates for LT in patients with concomitant HCC. Molecular markers of tumor progression are the strongest predictors of HCC recurrence currently available, surpassing all components of the tumor-node-metastasis classification system for staging of malignant tumors (TNM), including vascular invasion. Incorporation of these molecular markers of tumor progression could help resolve the ongoing conundrum of organ allocation for patients with HCC. KW - fai_index KW - hcc KW - hepatocellular_carcinoma KW - liver_cancer AU - Dvorchik, I AU - Schwartz, M AU - Fiel, MI AU - Finkelstein, SD AU - Marsh, JW PY - 2008/04// UR - http://dx.doi.org/10.1002/lt.21393 ER -