Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.

@article{citeulike:2910966, abstract = {The persistence of synaptic potentiation in the hippocampus is known to depend on transcription and protein synthesis. We report here that, under regimes of reduced protein synthesis, competition between synapses for the relevant intracellular proteins can be demonstrated. Under such circumstances, the induction of additional protein synthesis-dependent long-term potentiation for a given set of postsynaptic neurons occurs at the expense of the maintenance of prior potentiation on an independent pathway. This new phenomenon, which we call "competitive maintenance," has important functional consequences, and it may be explained in terms of dynamic interactions between synapses and "plasticity factors" over extended periods of time.}, address = {Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 M\"{u}nchen-Martinsried, Germany.}, author = {Fonseca, R. and N\"{a}gerl, U. V. and Morris, R. G. and Bonhoeffer, T. }, citeulike-article-id = {2910966}, doi = {http://dx.doi.org/10.1016/j.neuron.2004.10.033}, issn = {0896-6273}, journal = {Neuron}, keywords = {competition, ltp, molecular, synaptic\_plasticity, synaptic\_tagging}, month = {December}, number = {6}, pages = {1011--1020}, posted-at = {2008-06-20 17:16:56}, priority = {2}, title = {Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.}, url = {http://dx.doi.org/10.1016/j.neuron.2004.10.033}, volume = {44}, year = {2004} }

TY - JOUR ID - citeulike:2910966 L3 - citeulike-article-id:2910966 TI - Competing for memory: hippocampal LTP under regimes of reduced protein synthesis. JF - Neuron VL - 44 IS - 6 SP - 1011 EP - 1020 AD - Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 München-Martinsried, Germany. SN - 0896-6273 N2 - The persistence of synaptic potentiation in the hippocampus is known to depend on transcription and protein synthesis. We report here that, under regimes of reduced protein synthesis, competition between synapses for the relevant intracellular proteins can be demonstrated. Under such circumstances, the induction of additional protein synthesis-dependent long-term potentiation for a given set of postsynaptic neurons occurs at the expense of the maintenance of prior potentiation on an independent pathway. This new phenomenon, which we call "competitive maintenance," has important functional consequences, and it may be explained in terms of dynamic interactions between synapses and "plasticity factors" over extended periods of time. KW - competition KW - ltp KW - molecular KW - synaptic_plasticity KW - synaptic_tagging AU - Fonseca, R AU - Nägerl, UV AU - Morris, RG AU - Bonhoeffer, T PY - 2004/12/16/ UR - http://dx.doi.org/10.1016/j.neuron.2004.10.033 ER -