Cargo transport: molecular motors navigate a complex cytoskeleton

by: Jennifer L Ross, Yusuf M Ali, David M Warshaw

Current Opinion in Cell Biology, Vol. 20, No. 1. (February 2008), pp. 41-47.

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摘要

Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again.

@article{citeulike:2846839, abstract = {Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again.}, author = {Ross, Jennifer L. and Ali, Yusuf M. and Warshaw, David M. }, booktitle = {Cell structure and dynamics}, citeulike-article-id = {2846839}, doi = {http://dx.doi.org/10.1016/j.ceb.2007.11.006}, journal = {Current Opinion in Cell Biology}, keywords = {cargo\_attachment, dynein, kinesin, molecular\_motors, review}, month = {February}, number = {1}, pages = {41--47}, posted-at = {2008-07-18 19:50:57}, priority = {2}, title = {Cargo transport: molecular motors navigate a complex cytoskeleton}, url = {http://dx.doi.org/10.1016/j.ceb.2007.11.006}, volume = {20}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2846839 L3 - citeulike-article-id:2846839 TI - Cargo transport: molecular motors navigate a complex cytoskeleton T2 - Cell structure and dynamics JF - Current Opinion in Cell Biology VL - 20 IS - 1 SP - 41 EP - 47 N2 - Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again. KW - cargo_attachment KW - dynein KW - kinesin KW - molecular_motors KW - review AU - Ross, Jennifer AU - Ali, Yusuf AU - Warshaw, David PY - 2008/02// UR - http://dx.doi.org/10.1016/j.ceb.2007.11.006 ER -

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