Cytokines and the central nervous system

@article{citeulike:2805289, abstract = {cytokines and other products of the immune cells can modulate the action, differentiation, and survival of neuronal cells, while the neurotransmitter and neuropeptide release play a pivotal role in influencing the immune response. Cytokines and their receptors are constitutively expressed by and act on neurons in the central nervous system, in both its normal and its pathological state, but cytokine overexpression in the brain is an important factor in the pathogenesis of neurotoxic and neurodegenerative disorders. Accordingly, it can be accepted that the peripheral and central cytokine compartments appear to be integrated, and their effects might synergize or inhibit each other; however, it should always be taken into account that they are spatiotemporally differentially regulated. New concepts are reviewed in the regulation of relations between cytokine balance and neurodegeneration, including intracellular receptor-receptor, cell-cell, and systemic neuroimmune interactions that promote the further elucidation of the complexities and cascade of the possible interactions between cytokines and the central nervous system.}, author = {Szel\'{e}nyi, Judith }, citeulike-article-id = {2805289}, doi = {10.1016/S0361-9230(01)00428-2}, journal = {Brain Research Bulletin}, keywords = {cytokine-balance, cytokines, immunology, neuroendocrinology}, month = {March}, number = {4}, pages = {329--338}, posted-at = {2008-05-16 14:39:50}, priority = {0}, title = {Cytokines and the central nervous system}, url = {http://dx.doi.org/10.1016/S0361-9230(01)00428-2}, volume = {54}, year = {2001} }

TY - JOUR ID - citeulike:2805289 L3 - citeulike-article-id:2805289 TI - Cytokines and the central nervous system JF - Brain Research Bulletin VL - 54 IS - 4 SP - 329 EP - 338 N2 - cytokines and other products of the immune cells can modulate the action, differentiation, and survival of neuronal cells, while the neurotransmitter and neuropeptide release play a pivotal role in influencing the immune response. Cytokines and their receptors are constitutively expressed by and act on neurons in the central nervous system, in both its normal and its pathological state, but cytokine overexpression in the brain is an important factor in the pathogenesis of neurotoxic and neurodegenerative disorders. Accordingly, it can be accepted that the peripheral and central cytokine compartments appear to be integrated, and their effects might synergize or inhibit each other; however, it should always be taken into account that they are spatiotemporally differentially regulated. New concepts are reviewed in the regulation of relations between cytokine balance and neurodegeneration, including intracellular receptor-receptor, cell-cell, and systemic neuroimmune interactions that promote the further elucidation of the complexities and cascade of the possible interactions between cytokines and the central nervous system. KW - cytokine-balance KW - cytokines KW - immunology KW - neuroendocrinology AU - Szelényi, Judith PY - 2001/03/01/ UR - http://dx.doi.org/10.1016/S0361-9230(01)00428-2 ER -