Complete genome sequence of an M1 strain of Streptococcus pyogenes.

by: JJ Ferretti, WM McShan, D Ajdic, DJ Savic, G Savic, K Lyon, C Primeaux, S Sezate, AN Suvorov, S Kenton, HS Lai, SP Lin, Y Qian, HG Jia, FZ Najar, Q Ren, H Zhu, L Song, J White, X Yuan, SW Clifton, BA Roe, R McLaughlin

Proc Natl Acad Sci U S A, Vol. 98, No. 8. (10 April 2001), pp. 4658-4663.

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摘要

The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have been identified that encode proteins likely associated with microbial "molecular mimicry" of host characteristics and involved in rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenic potential.

@article{citeulike:2461330, abstract = {The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have been identified that encode proteins likely associated with microbial "molecular mimicry" of host characteristics and involved in rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenic potential.}, address = {Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA. Joe-Ferretti@ouhsc.edu}, author = {Ferretti, J. J. and McShan, W. M. and Ajdic, D. and Savic, D. J. and Savic, G. and Lyon, K. and Primeaux, C. and Sezate, S. and Suvorov, A. N. and Kenton, S. and Lai, H. S. and Lin, S. P. and Qian, Y. and Jia, H. G. and Najar, F. Z. and Ren, Q. and Zhu, H. and Song, L. and White, J. and Yuan, X. and Clifton, S. W. and Roe, B. A. and McLaughlin, R. }, citeulike-article-id = {2461330}, doi = {10.1073/pnas.071559398}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {genome}, month = {April}, number = {8}, pages = {4658--4663}, posted-at = {2008-03-03 18:02:05}, priority = {2}, title = {Complete genome sequence of an M1 strain of Streptococcus pyogenes.}, url = {http://dx.doi.org/10.1073/pnas.071559398}, volume = {98}, year = {2001} }

RIS record

TY - JOUR ID - citeulike:2461330 L3 - citeulike-article-id:2461330 TI - Complete genome sequence of an M1 strain of Streptococcus pyogenes. JF - Proc Natl Acad Sci U S A VL - 98 IS - 8 SP - 4658 EP - 4663 AD - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA. Joe-Ferretti@ouhsc.edu SN - 0027-8424 N2 - The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have been identified that encode proteins likely associated with microbial "molecular mimicry" of host characteristics and involved in rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenic potential. KW - genome AU - Ferretti, JJ AU - McShan, WM AU - Ajdic, D AU - Savic, DJ AU - Savic, G AU - Lyon, K AU - Primeaux, C AU - Sezate, S AU - Suvorov, AN AU - Kenton, S AU - Lai, HS AU - Lin, SP AU - Qian, Y AU - Jia, HG AU - Najar, FZ AU - Ren, Q AU - Zhu, H AU - Song, L AU - White, J AU - Yuan, X AU - Clifton, SW AU - Roe, BA AU - McLaughlin, R PY - 2001/04/10/ UR - http://dx.doi.org/10.1073/pnas.071559398 ER -

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