Therapeutic siRNAs.

by: M Sioud

Trends Pharmacol Sci, Vol. 25, No. 1. (January 2004), pp. 22-28.

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摘要

The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs. Recent studies demonstrate the general application of siRNAs to silence gene expression in a range of cell types and in whole mammals. Beyond their value for dissecting gene functions and target validation, siRNAs also hold great potential as gene-specific therapeutic agents.

@article{citeulike:198172, abstract = {The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs. Recent studies demonstrate the general application of siRNAs to silence gene expression in a range of cell types and in whole mammals. Beyond their value for dissecting gene functions and target validation, siRNAs also hold great potential as gene-specific therapeutic agents.}, address = {The Norwegian Radium Hospital, Department of Immunology, Molecular Medicine Group, Montebello, N-310, Oslo, Norway. mosioud@ulrik.uio.no}, author = {Sioud, M. }, citeulike-article-id = {198172}, issn = {0165-6147}, journal = {Trends Pharmacol Sci}, month = {January}, number = {1}, pages = {22--28}, posted-at = {2005-11-25 00:21:16}, priority = {2}, title = {Therapeutic siRNAs.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14723975}, volume = {25}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:198172 L3 - citeulike-article-id:198172 TI - Therapeutic siRNAs. JF - Trends Pharmacol Sci VL - 25 IS - 1 SP - 22 EP - 28 AD - The Norwegian Radium Hospital, Department of Immunology, Molecular Medicine Group, Montebello, N-310, Oslo, Norway. mosioud@ulrik.uio.no SN - 0165-6147 N2 - The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs. Recent studies demonstrate the general application of siRNAs to silence gene expression in a range of cell types and in whole mammals. Beyond their value for dissecting gene functions and target validation, siRNAs also hold great potential as gene-specific therapeutic agents. AU - Sioud, M PY - 2004/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/14723975 ER -

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