A host-targeting signal in virulence proteins reveals a secretome in malarial infection.

@article{citeulike:717101, abstract = {Malaria parasites secrete proteins across the vacuolar membrane into the erythrocyte, inducing modifications linked to disease and parasite survival. We identified an 11-amino acid signal required for the secretion of proteins from the Plasmodium falciparum vacuole to the human erythrocyte. Bioinformatics predicted a secretome of >320 proteins and conservation of the signal across parasite species. Functional studies indicated the predictive value of the signal and its role in targeting virulence proteins to the erythrocyte and implicated its recognition by a receptor/transporter. Erythrocyte modification by the parasite may involve plasmodial heat shock proteins and be vastly more complex than hitherto realized.}, address = {Departments of Pathology and Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA.}, author = {Hiller, N. L. and Bhattacharjee, S. and van Ooij, C. and Liolios, K. and Harrison, T. and Lopez-Estra\~{n}o, C. and Haldar, K. }, citeulike-article-id = {717101}, doi = {http://dx.doi.org/10.1126/science.1102737}, issn = {1095-9203}, journal = {Science}, keywords = {functional-prediction, interaction, secretome, virulence}, month = {December}, number = {5703}, pages = {1934--1937}, posted-at = {2006-06-30 09:39:18}, priority = {0}, title = {A host-targeting signal in virulence proteins reveals a secretome in malarial infection.}, url = {http://dx.doi.org/10.1126/science.1102737}, volume = {306}, year = {2004} }

TY - JOUR ID - citeulike:717101 L3 - citeulike-article-id:717101 TI - A host-targeting signal in virulence proteins reveals a secretome in malarial infection. JF - Science VL - 306 IS - 5703 SP - 1934 EP - 1937 AD - Departments of Pathology and Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. SN - 1095-9203 N2 - Malaria parasites secrete proteins across the vacuolar membrane into the erythrocyte, inducing modifications linked to disease and parasite survival. We identified an 11-amino acid signal required for the secretion of proteins from the Plasmodium falciparum vacuole to the human erythrocyte. Bioinformatics predicted a secretome of >320 proteins and conservation of the signal across parasite species. Functional studies indicated the predictive value of the signal and its role in targeting virulence proteins to the erythrocyte and implicated its recognition by a receptor/transporter. Erythrocyte modification by the parasite may involve plasmodial heat shock proteins and be vastly more complex than hitherto realized. KW - functional-prediction KW - interaction KW - secretome KW - virulence AU - Hiller, NL AU - Bhattacharjee, S AU - van Ooij, C AU - Liolios, K AU - Harrison, T AU - Lopez-Estraño, C AU - Haldar, K PY - 2004/12/10/ UR - http://dx.doi.org/10.1126/science.1102737 ER -