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所有的文献@标签 gpcr [429 articles]

当前文献的标签分类为: gpcr.
  • G-protein-coupled receptors: past, present and future.
    Br J Pharmacol, Vol. 147 Suppl 1 (January 2006)
    by SJ Hill
    posted to gpcr by xdeupi on 2006-03-01 16:33:55 as ***** along with 3 people and 2 groups allanlo Fritz merj neurolit LabCompMed
  • Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.
    J Biol Chem, Vol. 279, No. 9. (27 February 2004), pp. 8126-8132.
    by S Madabushi, AK Gross, A Philippi, EC Meng, TG Wensel, O Lichtarge
    posted to activation binding gpcr sequence switch by xdeupi on 2005-11-01 20:03:29 as read along with 2 people and 1 group gbart sriram_s LabCompMed
  • A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors.
    Proteins, Vol. 63, No. 4. (1 June 2006), pp. 1018-1030.
    by K Ye, EW Lameijer, MW Beukers, AP Ijzerman
    posted to activation gpcr sequence transmembrane by xdeupi on 2006-07-24 10:21:33 as **** along with 2 people and 1 group cen4ik cat_worth LabCompMed
  • A molecular dissection of the glycoprotein hormone receptors.
    Trends Biochem Sci, Vol. 29, No. 3. (March 2004), pp. 119-126.
    by G Vassart, L Pardo, S Costagliola
    posted to gpcr hormone structure thyrotropin by xdeupi on 2006-06-20 12:16:16 as ** along with 1 person and 1 group ndoelker LabCompMed
  • G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.
    Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715.
    by E Kostenis
    posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as **** along with 1 group LabCompMed
  • Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.
    Biochemistry, Vol. 42, No. 10. (18 March 2003), pp. 2759-2767.
    by T Mirzadegan, G Benkö, S Filipek, K Palczewski
    posted to sequence rhodopsin lmc_101 gpcr activation by xdeupi on 2005-11-01 19:50:18 as read along with 1 group LabCompMed
  • Molecular mechanism of 7TM receptor activation--a global toggle switch model.
    Annu Rev Pharmacol Toxicol, Vol. 46 (2006), pp. 481-519.
    by TW Schwartz, TM Frimurer, B Holst, MM Rosenkilde, CE Elling
    posted to activation gpcr helix modeling switch toggle by xdeupi on 2006-06-01 14:31:34 as read along with 1 person and 1 group superpyrin LabCompMed
  • Expression of Functional G Protein-Coupled Receptors in Photoreceptors of Transgenic Xenopus laevis.
    Biochemistry, Vol. 44, No. 44. (8 November 2005), pp. 14509-14518.
    by L Zhang, D Salom, J He, A Okun, J Ballesteros, K Palczewski, N Li
    posted to crystallography expression gpcr by xdeupi on 2005-11-04 22:17:03 as ** along with 1 group LabCompMed
  • Structures and spectral signatures of protonated water networks in bacteriorhodopsin.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 6980-6985.
    by G Mathias, D Marx
    posted to activation gpcr protonation retinal_binding_proteins rhodopsin theory water by xdeupi on 2007-06-11 10:25:44 as *** along with 1 person and 1 group saravan LabCompMed
  • The sequence of the human genome.
    Science, Vol. 291, No. 5507. (16 February 2001), pp. 1304-1351.
    by JC Venter, MD Adams, EW Myers, PW Li, RJ Mural, GG Sutton, HO Smith, M Yandell, CA Evans, RA Holt, JD Gocayne, P Amanatides, RM Ballew, DH Huson, JR Wortman, Q Zhang, CD Kodira, XH Zheng, L Chen, M Skupski, G Subramanian, PD Thomas, J Zhang, GL Gabor Miklos, C Nelson, S Broder, AG Clark, J Nadeau, VA McKusick, N Zinder, AJ Levine, RJ Roberts, M Simon, C Slayman, M Hunkapiller, R Bolanos, A Delcher, I Dew, D Fasulo, M Flanigan, L Florea, A Halpern, S Hannenhalli, S Kravitz, S Levy, C Mobarry, K Reinert, K Remington, J Abu-Threideh, E Beasley, K Biddick, V Bonazzi, R Brandon, M Cargill, I Chandramouliswaran, R Charlab, K Chaturvedi, Z Deng, V Di Francesco, P Dunn, K Eilbeck, C Evangelista, AE Gabrielian, W Gan, W Ge, F Gong, Z Gu, P Guan, TJ Heiman, ME Higgins, RR Ji, Z Ke, KA Ketchum, Z Lai, Y Lei, Z Li, J Li, Y Liang, X Lin, F Lu, GV Merkulov, N Milshina, HM Moore, AK Naik, VA Narayan, B Neelam, D Nusskern, DB Rusch, S Salzberg, W Shao, B Shue, J Sun, Z Wang, A Wang, X Wang, J Wang, M Wei, R Wides, C Xiao, C Yan, A Yao, J Ye, M Zhan, W Zhang, H Zhang, Q Zhao, L Zheng, F Zhong, W Zhong, S Zhu, S Zhao, D Gilbert, S Baumhueter, G Spier, C Carter, A Cravchik, T Woodage, F Ali, H An, A Awe, D Baldwin, H Baden, M Barnstead, I Barrow, K Beeson, D Busam, A Carver, A Center, ML Cheng, L Curry, S Danaher, L Davenport, R Desilets, S Dietz, K Dodson, L Doup, S Ferriera, N Garg, A Gluecksmann, B Hart, J Haynes, C Haynes, C Heiner, S Hladun, D Hostin, J Houck, T Howland, C Ibegwam, J Johnson, F Kalush, L Kline, S Koduru, A Love, F Mann, D May, S McCawley, T McIntosh, I McMullen, M Moy, L Moy, B Murphy, K Nelson, C Pfannkoch, E Pratts, V Puri, H Qureshi, M Reardon, R Rodriguez, YH Rogers, D Romblad, B Ruhfel, R Scott, C Sitter, M Smallwood, E Stewart, R Strong, E Suh, R Thomas, NN Tint, S Tse, C Vech, G Wang, J Wetter, S Williams, M Williams, S Windsor, E Winn-Deen, K Wolfe, J Zaveri, K Zaveri, JF Abril, R Guigó, MJ Campbell, KV Sjolander, B Karlak, A Kejariwal, H Mi, B Lazareva, T Hatton, A Narechania, K Diemer, A Muruganujan, N Guo, S Sato, V Bafna, S Istrail, R Lippert, R Schwartz, B Walenz, S Yooseph, D Allen, A Basu, J Baxendale, L Blick, M Caminha, J Carnes-Stine, P Caulk, YH Chiang, M Coyne, C Dahlke, A Mays, M Dombroski, M Donnelly, D Ely, S Esparham, C Fosler, H Gire, S Glanowski, K Glasser, A Glodek, M Gorokhov, K Graham, B Gropman, M Harris, J Heil, S Henderson, J Hoover, D Jennings, C Jordan, J Jordan, J Kasha, L Kagan, C Kraft, A Levitsky, M Lewis, X Liu, J Lopez, D Ma, W Majoros, J McDaniel, S Murphy, M Newman, T Nguyen, N Nguyen, M Nodell, S Pan, J Peck, M Peterson, W Rowe, R Sanders, J Scott, M Simpson, T Smith, A Sprague, T Stockwell, R Turner, E Venter, M Wang, M Wen, D Wu, M Wu, A Xia, A Zandieh, X Zhu
    posted to gpcr genome by xdeupi on 2007-01-22 17:48:23 as ** along with 21 people and 3 groups aramata Cortel jwortman jnemecek bicko Dax42 yas balajis arcticrasta dgront olympos incovoma naegele mimulus_99 brant frohike granujilla CitoJam renatomilani Neeperando sunliu Proteinkinases T_lab LabCompMed
  • G-protein-coupled receptor signalling through protein networks.
    Biochem Soc Trans, Vol. 35, No. Pt 1. (February 2007), pp. 23-27.
    by AD Strosberg, C Nahmias
    posted to b2ar gpcr pharmacology review structure by xdeupi on 2007-06-29 21:10:57 as ** along with 1 group LabCompMed
  • Agonist binding: a multistep process.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062.
    by B Kobilka
    posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as ** along with 1 group LabCompMed
  • The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 913-922.
    by C Ribas, P Penela, C Murga, A Salcedo, C García-Hoz, M Jurado-Pueyo, I Aymerich, F Mayor
    posted to activation arrestin gpcr grk by xdeupi on 2007-07-30 14:59:43 as ** along with 1 group LabCompMed
  • Melanocortin-1 receptor structure and functional regulation
    Pigment Cell Research, Vol. 18, No. 6. (December 2005), pp. 393-410.
    by Jose C Garcia-Borron, Berta L Sanchez-Laorden, Celia Jimenez-Cervantes
    posted to gpcr structure by xdeupi on 2005-11-11 22:11:21 as ** along with 1 group LabCompMed
  • Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.
    Trends Pharmacol Sci (28 October 2005)
    by Tommaso Costa, Susanna Cotecchia
    posted to activation cam gpcr by xdeupi on 2005-11-04 22:00:17 as **** along with 1 group LabCompMed
  • Peptide design and structural characterization of a GPCR loop mimetic.
    Biopolymers (18 April 2007)
    by Truc-Chi T C Pham, Richard W W Kriwacki, Abby L L Parrill
    posted to gpcr loops modeling structure by xdeupi on 2007-04-23 10:24:23 as ** along with 1 group LabCompMed
  • Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WxFG motif in the first loop.
    J Biol Chem (27 February 2006)
    by Jeffery M M Klco, Gregory V V Nikiforovich, Thomas J J Baranski
    posted to activation gpcr loops by xdeupi on 2006-03-06 10:13:22 as ** along with 1 group LabCompMed
  • A GPCR that is not "DRY".
    Mol Pharmacol, Vol. 68, No. 1. (July 2005), pp. 1-3.
    by CA Flanagan
    posted to activation dry gpcr ionic switch tm3 by xdeupi on 2006-05-23 12:08:02 as **** along with 1 group LabCompMed
  • Leukotriene B4 receptor and the function of its helix 8.
    J Biol Chem, Vol. 280, No. 37. (16 September 2005), pp. 32049-32052.
    by T Okuno, T Yokomizo, T Hori, M Miyano, T Shimizu
    posted to gpcr helix8 leukotriene by xdeupi on 2005-10-27 22:45:02 as ** along with 1 group LabCompMed
  • G-protein coupled receptor structure.
    Biochim Biophys Acta (10 October 2006)
    by Philip L L Yeagle, Arlene D D Albert
    posted to activation gpcr review rhodopsin structure by xdeupi on 2006-11-17 20:57:15 as ***** along with 4 people and 1 group gcaltabiano merj superpyrin adamsdi LabCompMed
  • G protein coupled receptor structure and activation.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 794-807.
    by BK Kobilka
    posted to switch review lmc_101 gpcr b2ar activation by xdeupi on 2007-06-02 19:19:32 as ** along with 4 people and 2 groups jyuh Fritz merj adamsdi neurolit LabCompMed
  • Helix packing moments reveal diversity and conservation in membrane protein structure.
    J Mol Biol, Vol. 337, No. 3. (26 March 2004), pp. 713-729.
    by W Liu, M Eilers, AB Patel, SO Smith
    posted to gpcr helix membrane_proteins rhodopsin sequence ser structure transmembrane by xdeupi on 2007-04-26 13:49:38 as ***** along with 1 group LabCompMed
  • Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.
    J Comput Aided Mol Des (7 November 2006)
    by Marta Filizola, Simon X Wang, Harel Weinstein
    posted to activation dynamics gpcr lipids md membrane rhodopsin structure by xdeupi on 2006-11-14 16:42:29 as ** along with 1 group LabCompMed
  • Interacting Residues in an Activated State of a G Protein-coupled Receptor
    J. Biol. Chem., Vol. 281, No. 4. (27 January 2006), pp. 2263-2272.
    by Yong-Hun Lee, Fred Naider, Jeffrey M Becker
    posted to activation gpcr by xdeupi on 2006-01-23 17:17:33 as *** along with 1 group LabCompMed
  • Structure-function of alpha1-adrenergic receptors.
    Biochem Pharmacol, Vol. 73, No. 8. (15 April 2007), pp. 1051-1062.
    by DM Perez
    posted to activation gpcr review by xdeupi on 2007-06-02 19:21:05 as ** along with 1 group LabCompMed
  • Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.
    J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719.
    by H Xhaard, VV Rantanen, T Nyrönen, MS Johnson
    posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as **** along with 1 group LabCompMed
  • Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling.
    J Comput Aided Mol Des, Vol. 20, No. 7-8. (g 2006), pp. 449-461.
    by F Fanelli, PG De Benedetti
    posted to gpcr modeling review by xdeupi on 2007-03-26 10:31:45 as ** along with 1 group LabCompMed
  • The first extracellular loop of the Saccharomyces cerevisiae GPCR STE2P undergoes a conformational change upon ligand binding.
    J Biol Chem (9 February 2007)
    by Melinda Hauser, Sarah Kauffman, Byung-Kwon K Lee, Fred Naider, Jeffrey M M Becker
    posted to activation binding gpcr loops by xdeupi on 2007-02-20 10:09:06 as ** along with 1 group LabCompMed
  • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
    Mol Pharmacol, Vol. 63, No. 6. (June 2003), pp. 1256-1272.
    by R Fredriksson, MC Lagerström, LG Lundin, HB Schiöth
    posted to evolution genome gpcr sequence by xdeupi on 2006-05-29 12:28:55 as read along with 2 people and 1 group happy_manatee adamsdi LabCompMed
  • Structural models of class a g protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.
    Curr Top Med Chem, Vol. 7, No. 10. (2007), pp. 999-1006.
    by X Deupi Nicole Dölker María Luz López-Rodríguez Mercedes Campillo Juan A Ballesteros And Leonardo Pardo, N Dölker, ML López-Rodríguez, M Campillo, JA Ballesteros, L Pardo
    posted to binding gpcr modeling plasticity structure by xdeupi on 2007-05-28 08:51:54 as ** along with 1 group LabCompMed
  • Latest development in drug discovery on G protein-coupled receptors.
    Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 465-470.
    by K Lundstrom
    posted to drug gpcr review by xdeupi on 2006-11-04 12:42:42 as ** along with 1 person and 1 group denissohy LabCompMed
  • Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling.
    BMC Biol, Vol. 3, No. 1. (2005)
    by K Scearce-Levie, MD Lieberman, HH Elliott, BR Conklin
    posted to gpcr internalization by xdeupi on 2006-01-30 09:25:41 as ** along with 1 group LabCompMed
  • Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells.
    Proc Natl Acad Sci U S A, Vol. 102, No. 51. (20 December 2005), pp. 18706-18711.
    by M Nobles, A Benians, A Tinker
    posted to dimer fret gpcr gproteins by xdeupi on 2006-02-06 08:53:47 as ** along with 1 group LabCompMed
  • GRK specificity for beta -arrestin recruitment to the beta 2-adrenergic receptor revealed by fluorescence resonance energy transfer.
    J Biol Chem (10 May 2006)
    by Jonathan D D Violin, Xiu-Rong R Ren, Robert J J Lefkowitz
    posted to arrestin b2ar fret gpcr by xdeupi on 2006-09-23 11:20:25 as *** along with 1 person and 1 group tkershaw LabCompMed
  • Heterologous GPCR Expression: A Bottleneck to Obtaining Crystal Structures.
    Biotechnol Prog (31 March 2007)
    by Emily C McCusker, Steven E Bane, Michelle A O'malley, Anne S Robinson
    posted to crystallography gpcr review by xdeupi on 2007-04-10 19:18:56 as ** along with 1 group LabCompMed
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 group LabCompMed
  • Transmembrane signaling by G protein-coupled receptors.
    Methods Mol Biol, Vol. 332 (2006), pp. 3-49.
    by LM Luttrell
    posted to activation erc_grant gpcr review by xdeupi on 2006-09-05 11:46:39 as ** along with 1 person and 3 groups dchughes G4ID LabCompMed Genetics-of-Gambling
  • Learning from the past: evolution of GPCR functions.
    Trends Pharmacol Sci (3 February 2007)
    by Torsten Schöneberg, Michael Hofreiter, Angela Schulz, Holger Römpler
    posted to evolution genome gpcr by xdeupi on 2007-02-27 11:08:24 as ** along with 1 group LabCompMed
  • Lessons from constitutively active mutants of G protein-coupled receptors.
    Trends Endocrinol Metab, Vol. 13, No. 8. (October 2002), pp. 336-343.
    by C Parnot, S Miserey-Lenkei, S Bardin, P Corvol, E Clauser
    posted to activation cam gpcr by xdeupi on 2005-11-01 20:08:05 as ** along with 1 group LabCompMed
  • The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
    Annu Rev Pharmacol Toxicol, Vol. 42 (2002), pp. 437-467.
    by L Shi, JA Javitch
    posted to agonist binding ecl2 gpcr helix loops transmembrane by xdeupi on 2005-11-01 01:00:19 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as ** along with 4 people and 1 group kuhn massivemayhem Ao_Li2007 yaredo LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • G-Protein-coupled receptorprotein interactions: Basis for new concepts on receptor structure and function
    Clinical and Experimental Pharmacology and Physiology, Vol. 32, No. 11. (November 2005), pp. 979-987.
    by Nanda Tilakaratne, Patrick M Sexton
    posted to gpcr by xdeupi on 2006-01-16 15:08:37 as ** along with 1 group LabCompMed
  • Synthesis of TOAC spin-labeled proteins and reconstitution in lipid membranes.
    Nat Protoc, Vol. 2, No. 1. (2007), pp. 42-49.
    by CB Karim, Z Zhang, DD Thomas
    posted to dynamics gpcr toac by xdeupi on 2007-04-10 19:30:43 as ** along with 1 group LabCompMed
  • Possible role of the 11-cis-retinyl conformation in controlling the dual decay processes of excited rhodopsin.
    Proc Natl Acad Sci U S A, Vol. 102, No. 31. (2 August 2005), pp. 10783-10787.
    by RS Liu, GS Hammond, T Mirzadegan
    posted to activation binding gpcr rhodopsin by xdeupi on 2005-11-01 19:48:57 as *** along with 1 group LabCompMed
  • A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.
    J Biol Chem, Vol. 269, No. 39. (30 September 1994), pp. 23879-23881.
    by S Arnis, K Fahmy, KP Hofmann, TP Sakmar
    posted to activation dry gpcr ionic lock mutation protonation rhodopsin tm3 by xdeupi on 2006-05-31 15:55:30 as ** along with 1 group LabCompMed
  • Seven transmembrane receptors: a brief personal retrospective.
    Biochimica et biophysica acta, Vol. 1768, No. 4. (April 2007), pp. 748-755.
    by RJ Lefkowitz
    posted to review lmc_101 gpcr by xdeupi on 2008-09-02 11:50:30 as ** along with 1 person IrinaMoreira
  • International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers.
    Pharmacol Rev, Vol. 59, No. 1. (March 2007), pp. 5-13.
    by JP Pin, R Neubig, M Bouvier, L Devi, M Filizola, JA Javitch, MJ Lohse, G Milligan, K Palczewski, M Parmentier, M Spedding
    posted to dimer gpcr review by xdeupi on 2007-03-12 14:26:45 as ** along with 1 group LabCompMed
  • Method To Assess Packing Quality of Transmembrane alpha-Helices in Proteins. 1. Parametrization Using Structural Data.
    J Chem Inf Model (20 March 2007)
    by Anton O Chugunov, Valery N Novoseletsky, Dmitry E Nolde, Alexander S Arseniev, Roman G Efremov
    posted to gpcr membrane_proteins modeling structure by xdeupi on 2007-03-26 10:07:02 as ** along with 1 person and 1 group superpyrin LabCompMed
  • Initial sequencing and analysis of the human genome
    Nature, Vol. 409, No. 6822. (15 February 2001), pp. 860-921.
    by Michael J Morgan
    posted to gpcr genome by xdeupi on 2007-01-22 18:06:19 as ** along with 20 people and 3 groups bozdagd cthachuk Cortel dragonrez jnemecek gg bicko Dax42 aprasad yas balajis dullhunk dgront djkt timflutre olympos nagendraproj incovoma yoanjacquemin brant Proteinkinases T_lab LabCompMed
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