giovanni's profile

Recent Activity

• 03:23: posted Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin expressing cells: Possible role of PPARgamma in the pathogenesis of huntington disease

• 16:09: posted The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation.

• 00:43: posted Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu.
• 00:41: posted Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.

• 16:49: posted Conservation and evolution of gene coexpression networks in human and chimpanzee brains
• 16:48: posted A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging.
• 16:47: posted Large-scale chemical dissection of mitochondrial function.
• 16:44: posted Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells.

• 16:17: posted Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.
• 16:14: posted Disorders of the cerebellum
• 16:11: posted Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity.

• 15:34: posted Bioinformatics and Computational Biology Solutions Using R and Bioconductor

• 15:28: posted Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.
• 15:22: posted Downregulation of peroxisme proliferator activated receptor gamma co-activator 1alpha in diabetic rats.
• 13:32: posted Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin.
• 13:32: posted The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle.
• 00:45: posted Friedreich ataxia.

• 21:44: posted Regulation of sterol synthesis in eukaryotes.

• 14:50: posted Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
• 14:42: posted PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

• 17:26: posted Regular insulin secretory oscillations despite impaired ATP synthesis in Friedreich Ataxia patients.
• 17:24: posted Genetic and family studies in Friedreich's ataxia.
• 17:05: posted Glucose tolerance and erythrocyte insulin receptors in Friedreich's ataxia.
• 16:56: posted Genetic data and natural history of Friedreich's disease: a study of 80 Italian patients.
• 16:30: posted Preclinical and manifest diabetes mellitus in young patients with Friedreich's ataxia: no evidence of immune process behind the islet cell destruction.
• 16:26: posted Evidence for abnormal regulation of insulin receptors in Friedreich's ataxia.
• 02:34: posted PGC-1alpha integrates insulin signaling, mitochondrial regulation and bioenergetic function in skeletal muscle
• 01:08: posted Etiology of insulin resistance.
• 00:54: posted Cross-talk between iron metabolism and diabetes.
• 00:31: posted Enzyme activities in quadriceps femoris muscle of obese diabetic male patients.
• 00:21: posted Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
• 00:20: posted Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.
• 00:11: posted Cellular mechanisms of insulin resistance.

• 23:25: posted Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.
• 23:20: posted Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.
• 23:12: posted Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.
• 23:10: posted Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.
• 22:53: posted Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.
• 22:04: posted Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians.
• 22:03: posted Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
• 21:55: posted Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

• 21:31: posted Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.
• 19:58: posted Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.

• 17:48: posted Animal models of Alzheimer's disease and frontotemporal dementia
• 10:55: posted Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts.
• 10:51: posted Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
• 10:13: posted A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.
• 09:57: posted Aluminum decreases the glutathione regeneration by the inhibition of NADP-isocitrate dehydrogenase in mitochondria.
• 09:56: posted Aluminum toxicity is associated with mitochondrial dysfunction and the production of reactive oxygen species in plant cells.
• 09:42: posted PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes.
• 09:12: posted The relationship between trinucleotide (GAA) repeat length and clinical features in Friedreich ataxia.
• 08:52: posted Glucose and insulin metabolism in Friedreich's ataxia.
• 08:50: posted Glucose intolerance in first-degree relatives of patients with Friedreich's ataxia is associated with insulin resistance: evidence for a closely linked inherited trait.
• 08:46: posted Glucose metabolism alterations in Friedreich's ataxia.
• 08:40: posted Glucose intolerance in Friedreich's ataxia: association with insulin resistance and decreased insulin binding.
• 08:39: posted Friedreich's ataxia and oral glucose tolerance: I. The effect of ingested glucose on serum glucose and insulin values in homozygotes, obligate heterozygotes and potential carriers of the Friedreich's ataxia gene.
• 08:19: posted Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia.
• 08:17: posted Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
• 08:07: posted Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.
• 07:59: posted Neurodegenerative disorders associated with diabetes mellitus.
• 07:41: posted Evidence of an increased number of type IIb muscle fibers in insulin-resistant first-degree relatives of patients with NIDDM.
• 02:53: posted Disabled early recruitment of antioxidant defenses in Friedreich's ataxia.
• 02:15: posted Nutrient control of glucose homeostasis through a complex of PGC-1[alpha] and SIRT1
• 01:59: posted Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.